Diabesity - novel molecular targets for obesity and type 2 diabetes
 
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Publications 2006
The following publications have arisen from DIABESITY in 2006:

Mature-Onset Obesity in Interleukin-1 Receptor I Knockout Mice
Maria C. Garcıa, Ingrid Wernstedt, Anna Berndtsson, Maria Enge, Michal Bell, Olof Hultgren, Michael Horn, Bo Ahren, Sven Enerback, Claes Ohlsson, Ville Wallenius and John-Olov Jansson

PARL Leu262Val is not associated with fasting insulin levels in UK populations
K. A. Fawcett, N. J. Wareham, J. Luan, H. Syddall, C. Cooper, S. O’Rahilly, I. N. M. Day,
M. S. Sandhu and I. Barroso


N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors
Johannes Grosse, Patrick Tarnow, Holger Römpler, Boris Schneider, Reinhard Sedlmeier, Ulrike Huffstadt, Dirk Korthaus, Michael Nehls, Sigrid Wattler, Torsten Schöneberg, Heike Biebermann and Martin Augustin

Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes
A.-H. Harding, R. J. F. Loos, J. Luan, S. ORahilly, N. J. Wareham & I. Barroso

Endocannabinoids and energy metabolism
U. Pagotto and R. Pasquali

Cannabinoid receptors as therapeutic targets for obesity and metabolic diseases
Luigi Bellocchio, Giacomo Mancini, Valentina Vicennati, Renato Pasquali and Uberto Pagotto

Leukemia inhibitory factor reduces body fat mass in ovariectomized mice
John-Olov Jansson, Sofia Moverare-Skrtic, Anna Berndtsson, Ingrid Wernstedt, Hans Carlsten and Claes Ohlsson

Interleukin-1 System Gene Polymorphisms Are Associated with Fat Mass in Young Men
Louise Strandberg, Mattias Lorentzon, Åsa Hellqvist, Staffan Nilsson, Ville Wallenius, Claes Ohlsson and John-Olov Jansson

Reduced stress and cold-induced increase in expenditure in interleukin-6-deficient mice
Ingrid Bergström, Ville Wallenius and John-Olov Jansson, Ingrid Wernstedt, Amanda Edgley, Anna Berndtsson, Jenny Fäldt, Göran

Distribution of ghrelin-immunoreactive neuronal networks in the human hypothalamus
Judit Menyhért, Gábor Wittmanna, Erik Hrabovszkya, Nóra Szlávik, Éva Kellerb,
Matthias Tschöp, Zsolt Liposits and Csaba Fekete

Hypothalamic proopiomelanocortin (POMC) neurons have a cholinergic phenotype
Björn Meister, Burcak Gömuc, Elisabet Suarez, Yuko Ishii, Katrin Durr and Linda Gillberg

Neuronal activation in the hypothalamus and brainstem during feeding in rats
Louise E. Johnstone, Tung M. Fong and Gareth Leng

Tamoxifen-Induced Anorexia Is Associated With Fatty Acid Synthase Inhibition in the Ventromedial Nucleus of the Hypothalamus and Accumulation of Malonyl-CoA
Miguel Lopez, Christopher J. Lelliott, Sulay Tovar, Wendy Kimber, Rosalıa Gallego, Sam Virtue, Margaret Blount, Maria J. Vazquez, Nick Finer, Trevor J. Powles, Stephen O’Rahilly, Asish K. Saha, Carlos Dieguez and Antonio J. Vidal-Puig

PC1/3 and PC2 Gene Expression and Post-Translational Endoproteolytic Pro-Opiomelanocortin Processing is Regulated by Photoperiod in the Seasonal Siberian Hamster (Phodopus sungorus)
M. Helwig, R. M. H. Khorooshi, A. Tups, P. Barrett, Z. A. Archer, C. Exner, J. Rozman, L. J. Braulke, J. G.
Mercer and M. Klingenspor


Deletion of Nicotinamide Nucleotide Transhydrogenase. A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice
Helen C. Freeman, Alison Hugill, Neil T. Dear, Frances M. Ashcroft and Roger D. Cox

11beta-Hydroxysteroid Dehydrogenase Type 1 Induction in the Arcuate Nucleus by High-Fat Feeding: A Novel Constraint to Hyperphagia?
Valerie S. Densmore, Nicholas M. Morton, John J. Mullins, and Jonathan R. Seckl

gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor
Ruth Janoschek, Leona Plum, Linda Koch, Heike Münzberg, Sabrina Diano, Marya Shanabrough, Werner Müller, Tamas L. Horvath and Jens C. Brüning

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
Leona Plum, Xiaosong Ma, Brigitte Hampel, Nina Balthasar, Roberto Coppari, Heike Münzberg, Marya Shanabrough, Denis Burdakov, Eva Rother, Ruth Janoschek, Jens Alber, Bengt F. Belgardt, Linda Koch, Jost Seibler, Frieder Schwenk, Csaba Fekete, Akira Suzuki, Tak W. Mak, Wilhelm Krone, Tamas L. Horvath, Frances M. Ashcroft, and Jens C. Brüning

Central insulin action in energy and glucose homeostasis
Leona Plum, Bengt F. Belgardt, and Jens C. Brüning

Expression of Vesicular Glutamate Transporter-2 in Gonadotrope and Thyrotrope Cells of the Rat Pituitary. Regulation by Estrogen and Thyroid Hormone Status
Erik Hrabovszky, Imre Kallo, Gergely F. Turi, Katalin May, Gabor Wittmann, Csaba Fekete, and
Zsolt Liposits


Ghrelin stimulates locomotor activity and accumbal dopamine-overflow via central cholinergic systems in mice: implications for its involvement in brain reward
Jerlhag E, Egecioglu E, Dickson SL, Andersson M, Svensson L and Engel JA

Uncoupling Protein 2 Has Protective Function during Experimental Autoimmune Encephalomyelitis
Susanne Vogler, Jens Pahnke, Sophie Rousset, Daniel Ricquier, Holger Moch, Bruno Miroux and Saleh M. Ibrahim

Psychiatric co-morbidities in patients attending specialist obesity services in the UK
A. Tuthill, H. Slawick, S. O’Rahily and N. Finer

Ghrelin action in the brain controls adipocyte metabolism
Claudia Theander-Carrillo, Petra Wiedmer, Philippe Cettour-Rose, Ruben Nogueiras,
Diego Perez-Tilve, Paul Pfluger, Tamara R. Castaneda, Patrick Muzzin, Annette Schürmann,
Ildiko Szanto, Matthias H. Tschöp, and Françoise Rohner-Jeanrenaud


Genetic Variation in 11 beta-Hydroxysteroid Dehydrogenase Type 1 Predicts Adrenal Hyperandrogenism among Lean Women with Polycystic Ovary Syndrome
Alessandra Gambineri, Valentina Vicennati, Silvia Genghini, Federica Tomassoni, Uberto Pagotto,
Renato Pasquali, and Brian R. Walker


Effects of Alpha-Melanocyte-Stimulating Hormone on Magnocellular Oxytocin Neurones and their Activation at Intromission in Male Rats
C. Caquineau, G. Leng, X. M. M. Guan, M. Jiang, L. Van der Ploeg and A. J. Douglas

Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and beta-Pancreatic Cells and in Obesity and Hyperglycemia
Isabel Matias, Marie-Paule Gonthier, Pierangelo Orlando, Vassilis Martiadis, Luciano De Petrocellis,
Cristina Cervino, Stefania Petrosino, Laurence Hoareau, Franck Festy, Renato Pasquali, Regis Roche,
Mario Maj, Uberto Pagotto, Palmiero Monteleone, and Vincenzo Di Marzo


The 103I variant of the melanocortin 4 receptor (MC4R) is associated with low serum triglyceride levels
Gunter Bronner, Alexander Sattler, Anke Hinney, Muhidien Soufi, Frank Geller, Helmut Schaefer, Bernhard Maisch, Johannes Hebebrand and Jeugen Schaefer

The emerging role of the endocannabinoid system in endocrine regulation and energy balance

Uberto Pagotto, Giovanni Marsicano, Daniela Cota, Beat Lutz, Renato Pasquali

Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice
Emil Egecioglu, Mikael Bjursell, Anna Ljungberg, Suzanne L. Dickson, John J. Kopchick,
Göran Bergström, Lennart Svensson, Jan Oscarsson, Jan Tornell and Mohammad Bohlooly

Interconnection between orexigenic neuropeptide Y- and anorexigenic α-melanocyte stimulating hormone-synthesizing neuronal systems of the human hypothalamus
Judit Menyhért, Gábor Wittmann, Erik Hrabovszky, Éva Keller, Zsolt Liposits, Csaba Fekete

Localization and osmotic regulation of vesicular glutamate transporter-2 in magnocellular neurons of the rat hypothalamus
E. Hrabovszky, A .K. Csapoa, I. Kallo, T. Wilheim, G.F. Turi, Z. Liposits

Oral Glucose load inhibits circulating ghrelin levels to the same extent in normal and obese children
Baldelli R., Bellone S., Castellino N., Petri A., Rapa A., Vivenza D., Bellone J., Broglio F., Ghigo E., Bona G.

Diabesity: Novel molecular targets for obesity and type 2 diabetes
   
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